If you ask a 100 different reloaders, you'll get a 100 different responses to which powder. The Lyman manual will highlight the most accurate load THEY found, with bold print. I love the choices. I tried to limit myself to just a couple of powders that were the most versatile. I love 4831, 4895, 5744, the SR series from IMR, No. 9, No. 7, No. 5 and No. 2 from Accurate Arms. There are too many for me to list! You will notice that for the 45 ACP, Blue Dot will fill a case nicely. But Blue Dot is too slow for that cartridge. It is up to the reloader to check for double charges. A LED flashlight is what I use, whether loading on a single stage or semi-progressive. In 40 years of reloading, I've had one double charge - 44 special and a double dose of HP-38. This was fired in a magnum revolver. I went home and pulled the rest of the loads apart but had that one that was double charged. Still load with HP-38. Nothing happened to the revolver or myself but it made me wiser. I inspect each cartridge as its being reloaded. That experience was on a single stage press.
I love the plethora of powders and new ones appear quite frequently! I load shotgun, pistol and rifle and may use powder like Unique to cover all three for certain loads, but there will be other powders that seem to work better. My 30-06 loves 2400 powder using a cast bullet better than Unique or Blue Dot. But Unique works in a pinch when I can't seem to find 2400 locally. Market sometimes dictates what powders are available to me unless I mail order.
take care,
r1kk1