There have been several WAR GAME type simulations in regards to biologicals
DARK WINTER was a biological attack simulation done in 2001 using small pox
TOPP OFF1 was a plague simulation done in 2000
TOPP OFF2 was done in 2003 and involved a radiological and a biological attack
Most university have pandemic plans in place and have run simulations on their effectiveness.
In all of these scenarios, the news was bad. If you think the response to Katrina was slow, it would pale in comparison to an epidemic like smallpox, or pandemic flu. Everyone has said there will be no vaccines, no help, no services. Everything would have to happen on a local level.
Biological agents are my biggest fear, and this is no tin foil hat thing. Sorry to ramble on by this stuff really freaks me out.