Author Topic: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China  (Read 55697 times)

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1140 on: May 22, 2020, 07:14:48 AM »
https://www.nytimes.com/2020/05/22/us/mississippi-church-arson-coronavirus.html
Church That Defied Coronavirus Restrictions Is Burned to Ground

First Pentecostal Church had sued the city of Holly Springs, Miss., which is about an hour southeast of Memphis, arguing that its stay-at-home order had violated the church’s right to free speech and interfered with its members’ ability to worship.

After firefighters put out the blaze early Wednesday, the police found a message, “Bet you stay home now you hypokrits,” spray-painted on the ground near the church’s doors, according to Maj. Kelly McMillen of the Marshall County Sheriff’s Department.

A photograph of the graffiti also appears to show an atomic symbol with an “A” in the center, which is sometimes used as a logo for atheist groups.

Offline Morning Sunshine

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1141 on: May 22, 2020, 07:52:48 AM »
https://www.nytimes.com/2020/05/22/us/mississippi-church-arson-coronavirus.html
Church That Defied Coronavirus Restrictions Is Burned to Ground

First Pentecostal Church had sued the city of Holly Springs, Miss., which is about an hour southeast of Memphis, arguing that its stay-at-home order had violated the church’s right to free speech and interfered with its members’ ability to worship.

After firefighters put out the blaze early Wednesday, the police found a message, “Bet you stay home now you hypokrits,” spray-painted on the ground near the church’s doors, according to Maj. Kelly McMillen of the Marshall County Sheriff’s Department.

A photograph of the graffiti also appears to show an atomic symbol with an “A” in the center, which is sometimes used as a logo for atheist groups.


there are those who are acting in ways that will not turn out well for them.  This will not end like they think it will end.

Offline FreeLancer

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1142 on: May 22, 2020, 02:00:58 PM »
While we're still waiting for the more definitive prospective studies to come out, this massive retrospective study was published today and it's not good news for the malaria drugs.


Lancet:  Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

Quote
Background

Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19.


Methods

We did a multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19. The registry comprised data from 671 hospitals in six continents. We included patients hospitalised between Dec 20, 2019, and April 14, 2020, with a positive laboratory finding for SARS-CoV-2. Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups (chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide), and patients who received none of these treatments formed the control group. Patients for whom one of the treatments of interest was initiated more than 48 h after diagnosis or while they were on mechanical ventilation, as well as patients who received remdesivir, were excluded. The main outcomes of interest were in-hospital mortality and the occurrence of de-novo ventricular arrhythmias (non-sustained or sustained ventricular tachycardia or ventricular fibrillation).


Findings

96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), when compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), hydroxychloroquine with a macrolide (23·8%; 1·447, 1·368–1·531), chloroquine (16·4%; 1·365, 1·218–1·531), and chloroquine with a macrolide (22·2%; 1·368, 1·273–1·469) were each independently associated with an increased risk of in-hospital mortality. Compared with the control group (0·3%), hydroxychloroquine (6·1%; 2·369, 1·935–2·900), hydroxychloroquine with a macrolide (8·1%; 5·106, 4·106–5·983), chloroquine (4·3%; 3·561, 2·760–4·596), and chloroquine with a macrolide (6·5%; 4·011, 3·344–4·812) were independently associated with an increased risk of de-novo ventricular arrhythmia during hospitalisation.


Interpretation

We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.


Quote
Evidence before this study

We searched MEDLINE (via PubMed) for articles published up to April 21, 2020, using the key words “novel coronavirus”, “2019-nCoV”, “COVID-19”, “SARS-CoV-2”, “therapy”, “hydroxychloroquine”, “chloroquine”, and “macrolide”. Moreover, we screened preprint servers, such as Medrxiv, for relevant articles and consulted the web pages of organisations such as the US National Institutes of Health and WHO. Hydroxychloroquine and chloroquine (used with or without a macrolide) are widely advocated for treatment of COVID-19 based on in-vitro evidence of an antiviral effect against severe acute respiratory syndrome coronavirus 2. Their use is based on small uncontrolled studies and in the absence of evidence from randomised controlled trials. Concerns have been raised that these drugs or their combination with macrolides could result in electrical instability and predispose patients to ventricular arrhythmias. Whether these drugs improve outcomes or are associated with harm in COVID-19 remains unknown.


Added value of this study

In the absence of reported randomised trials, there is an urgent need to evaluate real-world evidence related to outcomes with the use of hydroxychloroquine or chloroquine (used with or without macrolides) in COVID-19. Using an international, observational registry across six continents, we assessed 96 032 patients with COVID-19, of whom 14 888 were treated with hydroxychloroquine, chloroquine, or their combination with a macrolide. After controlling for age, sex, race or ethnicity, underlying comorbidities, and disease severity at baseline, the use of all four regimens was associated with an increased hazard for de-novo ventricular arrythmia and death in hospital. This study provides real-world evidence on the use of these therapeutic regimens by including a large number of patients from across the world. Thus, to our knowledge, these findings provide the most comprehensive evidence of the use of hydroxychloroquine and chloroquine (with or without a macrolide) for treatment of COVID-19.


Implications of all the available evidence

We found no evidence of benefit of hydroxychloroquine or chloroquine when used either alone or with a macrolide. Previous evidence was derived from either small anecdotal studies or inconclusive small randomised trials. Our study included a large number of patients across multiple geographic regions and provides the most robust real-world evidence to date on the usefulness of these treatment regimens. Although observational studies cannot fully account for unmeasured confounding factors, our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens (with or without a macrolide) in hospitalised patients with COVID-19.




Look at Figure 2: Independent predictors of in-hospital mortality and notice that treatment with antimalarials increased the odds of death among the almost 15,000 patients in this study's treatment group, worse than many of the other risk factors we've been worried about, like COPD and smoking.
« Last Edit: May 22, 2020, 02:08:30 PM by FreeLancer »

Offline David in MN

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1143 on: May 22, 2020, 04:56:57 PM »
Wow! COVID has nearly cured cancer! Some cancer screenings are down by as much as 80%. Breast cancer screenings have fallen by nearly 2/3. Hospitals are near empty.

Add on to that the incredible health strides we've made with these "lockdowns". We've protected society from the undue stress of gyms, the cancerous sunlight that provides no value to the human body, the danger of congregating at farmers' markets, and pretty much any social interaction.

One must wonder how many other diseases will be suppressed when we release these super-immunos into the streets after months of hardening themselves on cake, getting their only human interaction through screens, and of course, avoiding the deadly human contact.

Is it too hard to suggest, sarcasm aside, that we are going to see some massive second and third order effects by this overreaction? Parents aren't even taking kids in for vaccines so we actually risk some MMR issues come fall. And that one kills the kiddies when we slack on it.

What happens if the lack of COVID puts many hospitals out of business and then come "all clear" the few remaining get soaked in a myriad of long term issues? Has anyone played the counterfactual in any level of our government?

Offline Mr. Bill

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1144 on: May 22, 2020, 05:14:45 PM »
While we're still waiting for the more definitive prospective studies to come out, this massive retrospective study was published today and it's not good news for the malaria drugs.


Lancet:  Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

That is really unfortunate news.  I'm sure we've all been hoping for a more positive effect.  The authors are careful to note the limitations of their study, and state that "a cause-and-effect relationship between drug therapy and survival should not be inferred."  But sheesh, this is a death rate increase of one-third or more, for patients given the drugs.  And it's a really large sample size, compared with most studies.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1145 on: May 22, 2020, 06:11:30 PM »
Time to open up.

https://www.cnbc.com/amp/2020/05/22/dr-anthony-fauci-says-staying-closed-for-too-long-could-cause-irreparable-damage.html
Dr. Anthony Fauci says staying closed for too long could cause 'irreparable damage'

Stay-at-home orders intended to curb the spread of the coronavirus could end up causing "irreparable damage" if imposed for too long, White House health advisor Dr. Anthony Fauci told CNBC on Friday.

"I don't want people to think that any of us feel that staying locked down for a prolonged period of time is the way to go," Fauci said during an interview with CNBC's Meg Tirrell on "Halftime Report."

He said the U.S. had to institute severe measures because Covid-19 cases were exploding then. "But now is the time, depending upon where you are and what your situation is, to begin to seriously look at reopening the economy, reopening the country to try to get back to some degree of normal."

Offline FreeLancer

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1146 on: May 22, 2020, 06:38:18 PM »
But sheesh, this is a death rate increase of one-third or more, for patients given the drugs.  And it's a really large sample size, compared with most studies.

It’s huge.

It doesn’t diminish the necessity for prospective clinical trials, but it’s a stark warning.

Offline Mr. Bill

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1147 on: May 22, 2020, 07:52:51 PM »
Time to open up.

During the opening-up, I'm sure most of us are very concerned about how to weigh COVID-19 risks, what precautions to take, etc. Here is a very good overview by James H. Stein, MD, a cardiovascular researcher at the University of Wisconsin.

This post is 16 days old, which is antique in coronavirus terms, so some of his statistics may have been updated. Also note that he mentions both "case fatality rate" (deaths per CONFIRMED case, which is alarmingly high) and "infection fatality rate" (deaths per actual infection, which is substantially lower because of all the undiagnosed COVID-19 infections).

With these caveats, I think this article is a big help in deciding how to manage risks for your personal situation.

https://www.facebook.com/james.stein.1964/posts/1677778515735882

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1148 on: May 22, 2020, 10:53:05 PM »
There was no need to send contagious people back to nursing homes in NYC.  There were entire hospitals sitting unused.  Tens of thousands died needlessly. 

https://thecity.nyc/2020/05/brooklyn-field-hospital-in-red-hook-shuts-after-no-patients.html
BROOKLYN FIELD HOSPITAL SHUTS AFTER $21 MILLION CONSTRUCTION — AND ZERO PATIENTS

Offline Mona

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1149 on: May 23, 2020, 03:38:12 AM »
There was no need to send contagious people back to nursing homes in NYC.  There were entire hospitals sitting unused.  Tens of thousands died needlessly. 

https://thecity.nyc/2020/05/brooklyn-field-hospital-in-red-hook-shuts-after-no-patients.html
BROOKLYN FIELD HOSPITAL SHUTS AFTER $21 MILLION CONSTRUCTION — AND ZERO PATIENTS

someone might have done the math on costs of care right then and made that call. But I agree, there must have been a better way. I wonder how good the staffing situation was/would have been in those field hospitals, it seems to be a lot easier to build some hospital than to find qualified staff, especially in a situation where many of them are getting sick.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1150 on: May 23, 2020, 06:39:44 AM »
More good news.  Though, it would have been nice for CDC to listen to scientists months ago and not spread so much misinformation. The constant flip-flops don't help build confidence.

https://www.foxnews.com/health/cdc-now-says-coronavirus-does-not-spread-easily-via-contaminated-surfaces
CDC now says coronavirus 'does not spread easily' via contaminated surfaces

Offline Greekman

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1151 on: May 23, 2020, 10:17:02 AM »
fixed it for you......
The constant flip-flops don't help build confidence and trust.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1152 on: May 23, 2020, 12:17:03 PM »
This needs to be addressed.

https://www.startribune.com/minn-nursing-homes-already-site-of-81-of-covid-19-deaths-still-taking-in-infected-patients/570601282/
Minnesota nursing homes, already the site of 81% of COVID-19 deaths, continue taking in infected patients
Nursing homes accepting infected patients, even as death toll mounts.


Despite the devastating death toll, Minnesota nursing homes are still being allowed by state regulators to admit coronavirus patients who have been discharged from hospitals.

Early in the pandemic, the Minnesota Department of Health turned to nursing homes and other long-term care facilities to relieve the burden on hospitals that were at risk of being overwhelmed by COVID-19 patients. Minnesota hospitals have since discharged dozens of infected patients to nursing homes, including facilities that have undergone large and deadly outbreaks of the disease, state records show.

Now that practice is drawing strong opposition from some lawmakers, residents’ families and health watchdogs, who warn that such transfers endanger residents of senior homes that are understaffed and ill-equipped to contain the spread of the coronavirus. They are calling for more state scrutiny over transfers, including stricter standards over which nursing homes should be allowed to accept COVID-19 patients from hospitals.

Offline David in MN

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1153 on: May 24, 2020, 09:08:14 PM »
Ugh. Could I get a break from the absolute horse-crap messaging? Why do I have to sit through people like Neil Degrass Tyson and Bill Nye telling me to "trust the science"? First off, the experts got it all wrong, made faulty tests, mandated only their faulty tests could be used, and then determined that every hangnail, boating accident, and runny poop were COVID symptoms. They literally went so far as to say anything in line with the symptoms was COVID. So when you show up at the hospital with a farm auger through your torso please don't sneeze because you'll be a COVID case. Screw the experts. It's an interesting case study with COVID: Better off sending billions of dollars to the WHO and CDC or buying uncle Jim-Bob a case of whiskey and letting him remind you to warsh yer hands and shut yer cake-hole?

Then there's the advertisers. Oh Lord how I want to be free of them. Every damn commercial is the same. Here's a parody that drives it home:

https://www.youtube.com/watch?v=iNWsC9lRGzQ

Like for Pete's sake I'm going to buy a laundry detergent because of some morose piano backed "together we'll move forward" BS. I don't care about this crap when I'm buying any product. If you make a good sandwich I'll knock down your door.

Could we have any honest dialogue?

Offline FreeLancer

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1154 on: May 24, 2020, 09:56:57 PM »
Screw the experts.

Could we have any honest dialogue?

I guess not.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1155 on: May 27, 2020, 08:51:26 AM »
Yesterday afternoon:

https://amp.theguardian.com/us-news/2020/may/26/andrew-cuomo-nursing-home-execs-immunity
Andrew Cuomo gave immunity to nursing home execs after big campaign donations
Critics say data proves New York’s liability shield is linked to higher nursing home death rates during the pandemic


Yesterday evening:

https://www.nationalreview.com/news/cuomo-coronavirus-order-forcing-nursing-homes-to-take-covid-19-patients-scrubbed-from-new-york-state-website/amp/
Order Forcing Nursing Homes to Take Covid Patients Scrubbed from N.Y. State Website

The New York Department of Health has apparently deleted a March order issued by Governor Andrew Cuomo that forced nursing homes to admit Covid-positive residents.

The order, which was implemented on March 25, stated that “no resident shall be denied re-admission or admission to a nursing home solely based on a confirmed or suspected diagnosis of COVID-19,” and also prohibited nursing homes from requiring testing prior to admission or readmission. But the order is no longer visible on the state’s website.

Offline Greekman

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1156 on: May 27, 2020, 11:08:35 AM »
Starting June the 1st, greece will amke available the vaccination with the BCG vaccine.
It will be administered as ageneral population research program, and for those older than 50 only.

Offline ChEng

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1157 on: May 27, 2020, 01:07:19 PM »
Starting June the 1st, greece will amke available the vaccination with the BCG vaccine.
...
What is BCG? Sorry, but the only BCG of which I am aware is the government issued BCGs (Birth Control Glasses - they made you look so ugly, that you could not reproduce while wearing them,  :P ) that the guys with poor vision were issued in basic training.

Offline Mr. Bill

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1158 on: May 27, 2020, 01:36:15 PM »
Wikipedia: BCG vaccine

Quote
Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). ...

Nature Reviews Immunology, 5/11/20: BCG-induced trained immunity: can it offer protection against COVID-19?

Quote
Bacillus Calmette–Guérin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. ...

Offline FreeLancer

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1159 on: May 27, 2020, 09:52:20 PM »
Cumulative Cases/Deaths per Million Population

Nation/State         Cases/mil Deaths/mil
Belgium4,971808
Spain6,071580
UK ^x13,939552
Italy3,822547
France2,803438
Sweden3,476418
US5,277309
Canada  2,321179
Germany2,172102
Turkey1,89753
Norway1,55143
Czechia84930
Greece27817
Japan 1327
S Korea2215
--- --- ---
New York19,2601,519
New Jersey17,7681,277
Connecticut 11,5811,067
Massachusetts 13,670950
Washington, DC11,911631
Rhode Island ^x2 13,549618
Louisiana8,283586
Michigan5,568534
Pennsylvania 5,753416
Illinois ^x19,020401
Maryland 8,010396
Delaware 9,341353
Indiana 4,818302
Colorado 4,301242
Mississippi 4,719225
Georgia 4,204182
Ohio 2,866176
Minnesota ^x13,983165
New Hampshire ^x23,152164
Iowa ^x45,820157
New Mexico ^x13,459157
Virginia ^x14,715150
Washington2,813144
Nevada 2,634131
Alabama 3,270119
Missouri 2,088115
Arizona 2,372114
Florida 2,451108
California ^x12,570100
Wisconsin ^x12,82793
South Carolina ^x22,06391
Kentucky ^x12,03290
Vermont 1,55687
Nebraska ^x36,70884
Oklahoma 1,57481
North Carolina  2,37480
Kansas 3,23173
North Dakota 3,20173
South Dakota ^x15,32461
Maine 1,59060
Texas 2,03955
Tennessee 3,12052
Idaho 1,52846
West Virginia 1,06041
Arkansas 2,08040
Oregon 95735
Utah 2,71633
Wyoming 1,48624
Montana 45016
Alaska 56316
Hawaii 45512


Global deaths are now at 357,432 and 102,107 of those are in the US.  The UK has now surpassed Italy's per capita death rate, and will likely surpass Spain's soon.


I added Washington, DC to the list, given its high per capita rates, which are accelerating at a higher rate than many other states.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1160 on: May 27, 2020, 11:17:16 PM »
Studies Jack talked about yesterday.

https://theprint.in/health/hcq-breakthrough-icmr-finds-its-effective-in-preventing-coronavirus-expands-its-use/427583/
HCQ breakthrough: ICMR finds it’s effective in preventing coronavirus, expands its use
Three studies find that hydroxychloroquine reduces chances of contracting Covid, so ICMR allows more frontline workers to take it as a preventive drug.


New Delhi: The Indian Council of Medical Research (ICMR), the country’s apex body in the field, has found that consuming the drug hydroxychloroquine reduces the chances of getting infected with Covid-19.

As a result, ICMR released an advisory Friday to expand the usage of HCQ — an anti-malarial drug — as a preventive treatment against the novel coronavirus.
...
The advisory suggests surveillance workers, paramilitary and police personnel, as well as medical staff working in non-Covid hospitals and blocks to start consuming the pill as “preventive therapy”.
...
According to the advisory, the premier health body undertook investigation at three central government hospitals in New Delhi. While it did not reveal the names of the hospitals, it said the investigation indicates that “amongst healthcare workers involved in Covid-19 care, those on HCQ prophylaxis were less likely to develop SARS-CoV-2 infection, compared to those who were not on it”.

Offline ChEng

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1161 on: May 28, 2020, 04:17:09 AM »
Wikipedia: BCG vaccine

Nature Reviews Immunology, 5/11/20: BCG-induced trained immunity: can it offer protection against COVID-19?
Interesting that they are thinking that a bacterial vaccine could be effective against a viral disease.

Offline Greekman

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1162 on: May 28, 2020, 08:37:41 AM »
Interesting that they are thinking that a bacterial vaccine could be effective against a viral disease.

Well, the keywords are "innate immune mechanisms, also termed trained immunity'
That is the body trains its immune system to combat viruses etc. It may happen that the already setup mechanism for defending against tuberculosis copes well against Covid-19...

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1163 on: May 30, 2020, 06:51:14 AM »
You know there is a problem when researchers refuse to provide even rudimentary data to peers to check.  Sad that scientists have to now run letter campaigns to just receive the list of where data came from.  The dsconnects are blatantly obvious.  It's likely the study is severely flawed and maybe even fraudulent.

https://thehill.com/policy/healthcare/500236-massive-hydroxychloroquine-study-raising-health-concerns-about-the-drug?amp
Massive hydroxychloroquine study raising health concerns about the drug under scrutiny from scientists

A massive study that raised health concerns over hydroxychloroquine, the anti-malaria drug touted by President Trump as a coronavirus treatment, is coming under scrutiny from scientists who are demanding to see the data behind it.

The scientists expressed concerns over a high-profile study from The Lancet, which surveyed 96,000 hospitalized COVID-19 patients across six continents and concluded that the drug was ineffective in fighting the coronavirus and caused serious heart problems and even death for patients who had the disease.

An open letter from more than 180 scientists around the world raised concerns over what they said was inconsistent data in the report, noting that the average daily doses of hydroxychloroquine were higher than the those recommended by the U.S. Food and Drug Administration (FDA).

They also pointed out that data the magazine said was from Australian patients did not seem to match data from the Australian government, among other things.

Another major concern was that the study's authors did not release their code or data despite signing a pledge to share information on the coronavirus.

The report "has led many researchers around the world to scrutinize in detail the publication in question. This scrutiny has raised both methodological and data integrity concerns," the scientists wrote, adding that they were asking the Lancet to make available the peer review process that "led to this manuscript being accepted for publication."


Offline LvsChant

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1164 on: May 30, 2020, 08:11:21 AM »
Another thing that has been mentioned is the speed at which the data was supposedly collected and analyzed with only four authors listed. That in itself seems incredible.

The fact that they will not release the underlying data to their peers is concerning.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1165 on: May 30, 2020, 08:51:17 AM »
Another thing that has been mentioned is the speed at which the data was supposedly collected and analyzed with only four authors listed. That in itself seems incredible.

The fact that they will not release the underlying data to their peers is concerning.

Even simple glance shows tables are mathematically inconsistent.  You can't read it without it being blaringly obvious, e.g. there is no way the Australian data is right as there are four different numbers given for hospitals.  But biggest point is that it appears fraudulent.  Dosages reported don't match any course of known treatment nor do stats on standard treatment.  Not a single hospital has confirm they provided data for the study.  And the study authors refuse to release names of hospitals or even set up anonymized phone conversations with hospital representatives to show data just wasn't made up.  Never seen anything like this ever in a published, peer reviewed study.  The Lancet needs to pull it ASAP not just issue warnings of discrepancies.  Very bad optics.

Offline Mr. Bill

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1166 on: June 02, 2020, 05:20:43 PM »
Lancet:  Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

Lancet, 6/2/20: Expression of concern: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

Quote
Important scientific questions have been raised about data reported in the paper by Mandeep Mehra et al — Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis — published in The Lancet on May 22, 2020. Although an independent audit of the provenance and validity of the data has been commissioned by the authors not affiliated with Surgisphere and is ongoing, with results expected very shortly, we are issuing an Expression of Concern to alert readers to the fact that serious scientific questions have been brought to our attention. We will update this notice as soon as we have further information.

The Lancet Editors

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1167 on: June 02, 2020, 05:55:50 PM »
Yeah, retrospective studies suck.  There's way too much room for bias and data set manipulation to creep into the process. 

Until there's data from multiple independent prospective clinic trials, we're still flying mostly blind.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1168 on: June 03, 2020, 07:20:09 AM »
One of my biophysics friends says they are calling it the Steele Dossier of medicine.  Amazing how easily they got taken in by a couple of Charlatans.

https://arstechnica.com/science/2020/06/doubt-looms-over-hydroxychloroquine-study-that-halted-global-trials/
Doubt looms over hydroxychloroquine study that halted global trials

In addition to a lack of transparency over the data, a report by The Scientist magazine also noted that Surgisphere’s founder, Dr. Sapan Desai, has a less than pristine past. The magazine noted that Desai, who trained in vascular surgery and founded the company in 2008, resigned from a hospital position shortly after three medical malpractice suits were filed against him in 2019.

Further, before Desai and Surgisphere focused on data analytics, their most public-facing activity was selling medical textbooks. According to The Scientist, the textbooks had fake 5-star reviews on Amazon from accounts impersonating actual physicians. One of the impersonated physicians, a breast surgical oncologist, told the magazine that she and colleagues eventually got Amazon to remove the reviews.

Offline iam4liberty

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Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1169 on: June 03, 2020, 11:24:14 AM »
Trials are on again.

https://www.marketwatch.com/amp/story/guid/1753DE67-72B0-4DF1-A0FD-6F88912FE3AD
WHO to resume hydroxychloroquine study

The World Health Organization (WHO) said Wednesday that it will resume its clinical trial evaluating hydroxychloroquine as a treatment for COVID-19 following safety concerns. "On the basis of the available mortality data, the members of the committee recommended that there are no reasons to modify the trial protocol," Dr. Tedros Adhanom Ghebreyesus, WHO's director-general, wrote on Twitter.