Author Topic: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China  (Read 64440 times)

Offline FreeLancer

  • Global Moderator
  • Survival Veteran
  • ******
  • Posts: 6696
  • Karma: 819
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1320 on: July 29, 2020, 08:23:45 PM »
Regarding Big Pharma suppressing HCQ because it's cheap and not patent-controlled...  This person said it better than I can:

More here (warning for coarse language):
https://www.facebook.com/yvetteguinevere/posts/10100347097800474

Truth.

Offline iam4liberty

  • Survival Veteran
  • ********
  • Posts: 5063
  • Karma: 358
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1321 on: July 29, 2020, 10:20:37 PM »
That post is a total joke.  Doesn't even make one cogent argument against any of the studies.  Even the ones where they claim "no statistically significant" effect show big descriptive effect.  It is just a matter of base size as shown by meta-analysis.

More to the point, since hydroxychloroquine is safe, why not let doctors prescribe it just like they are doing in several other countries?  Instead they are actively interfering with the doctor patient relationship.  It is especially funny when people argue against federal involvement to stop riots citing a local control argument then turn around and pull out all the stops in preventing clinical use, research, or even mentioning the name in an online video.  It is going to be funny when all the pro-choicers march and everyone responds, "Sorry, if we can ban hydroxychloroquine then we can ban abortions too. 

There simply have been zero legitimate arguments made that merit the  anti-hydroxychloriquine mania.  Hence why everyone is skeptical of the motives of those pushing that narrative.
« Last Edit: July 29, 2020, 10:27:41 PM by iam4liberty »

Offline FreeLancer

  • Global Moderator
  • Survival Veteran
  • ******
  • Posts: 6696
  • Karma: 819
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1322 on: July 30, 2020, 12:10:07 AM »
There’s no shortage of docs willing to prescribe hydroxychloroquine, if you want it.

Offline Mr. Bill

  • Like a hot cocoa mojito
  • Administrator
  • Ultimate Survival Veteran
  • *******
  • Posts: 15270
  • Karma: 1875
  • Trained Attack Sheepdog/Troll hunter
    • Website Maintenance and Online Presence Management by Mr. Bill
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1323 on: July 30, 2020, 08:28:26 AM »
That post is a total joke.  Doesn't even make one cogent argument against any of the studies. ...

It was an angry editorial, not a compilation of evidence.  The key point was in the section I quoted.  If there's a conspiracy between Big Pharma and Democrats to suppress HCQ, why is there no similar conspiracy to suppress dexamethazone?

There is no conspiracy.  There's just a whole lot of medical professionals and researchers who honestly believe HCQ is the wrong drug for COVID.

Offline iam4liberty

  • Survival Veteran
  • ********
  • Posts: 5063
  • Karma: 358
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1324 on: July 30, 2020, 06:13:15 PM »
It was an angry editorial, not a compilation of evidence.  The key point was in the section I quoted.  If there's a conspiracy between Big Pharma and Democrats to suppress HCQ, why is there no similar conspiracy to suppress dexamethazone?

You're kidding, right?  Dexamethazone faced an onslaught in the media just like hydroxychloroquine.  It was the same medical personel who defended hydroxychloroquine who defended dexamethazone.  It is one of the three treatments promoted by the frontline doctors, for different stages of the disease.The only difference was in the rabidity of the attacks with hydroxychloroquine being more vicious because the president used it. 

Here is just a handful of thousands of such articles when you do a google search.

https://www.fiercepharma.com/pharma/dexamethasone-really-a-covid-19-breakthrough-not-so-fast-doctors-say
Is dexamethasone really a COVID-19 breakthrough? Not so fast, doctors say
Not long after researchers in England said the low-cost steroid dexamethasone reduced deaths among hospitalized COVID-19 patients, health experts around the world started raising alarm bells about the study—and the extreme enthusiasm it generated.

https://meaww.com/hype-over-dexamethasone-covid-19-cure-might-prove-to-be-costly-break-peoples-trust-in-science
Hype over dexamethasone as Covid-19 cure might prove to be costly and break people's trust in science: Expert

https://m.businesstoday.in/story/coronavirus-pandemic-us-doctors-view-reported-success-of-dexamethasone-with-skepticism/1/407167.html
Coronavirus pandemic: US doctors view reported success of dexamethasone with skepticism

https://www.cnbc.com/2020/06/17/coronavirus-update-who-urges-caution-on-dexamethasone-citing-early-data.html
WHO urges caution on ‘breakthrough’ coronavirus drug dexamethasone, citing early data
The World Health Organization is urging the public to be cautious about dexamethasone...it was only one study, a WHO official said.

https://www.newsmax.com/health/health-news/dexamethasone-COVID-19-felony-charges/2020/06/17/id/972689/
Buying Dexamethasone Online for COVID-19 Could Be Dangerous

https://www.sciencedaily.com/releases/2020/02/200206110703.htm
Steroids could do more harm than good in treating coronavirus

https://www.techarp.com/science/dexamethasone-covid-19-danger/
Dexamethasone : Do NOT Self-Medicate Against COVID-19!
Find out how dexamethasone helps against COVID-19, and why you should NOT use dexamethasone

https://www.thenewsminute.com/article/dexamethasone-wonder-cure-covid-19-doctor-writes-127297
Is Dexamethasone the wonder cure for COVID-19? A doctor writes
The headlines around this drug lack the context that helps us understand the limits of its benefits.


https://m.hindustantimes.com/health/hydroxychloroquine-dexamethasone-remdesivir-desperation-science-slows-the-hunt-for-coronavirus-solutions/story-rFfOhH330j77QIs3iAo6XL.html
Hydroxychloroquine, dexamethasone, remdesivir: ‘Desperation science’ slows the hunt for coronavirus solutions


The truth be told, deamethazone was dead in the water until Boris Johnson almost died and afterwards ordered large sample trials so the results were incontrovertable.  This is exactly what scientists wanted for hydroxychloroquine but WHO and the fake studies published in The Lancet and other medical journals disrupted those.

https://www.sciencemag.org/news/2020/07/one-uk-trial-transforming-covid-19-treatment-why-haven-t-others-delivered-more-results
One U.K. trial is transforming COVID-19 treatment. Why haven’t others delivered more results?

It’s very, very rare that you announce results at lunchtime, and it becomes policy and practice by tea time, and probably starts to save lives by the weekend,” Landray told Science at the time of the steroid result.

Large, randomized trials are the gold standard to test a drug’s efficacy. But they have been scarce so far in the COVID-19 pandemic. “Everybody has the first part about “randomized,” but they omitted the “large” part...Every clinician, every researcher wants to help and then they end up having a trial with 300 or 400 patients that cannot come up with conclusive evidence.”

One reason Recovery has done so well is that it was backed by the United Kingdom’s centralized National Health Service (NHS), involving 176 of its hospitals.


https://www.everythingzoomer.com/health/2020/06/16/covid-19-u-k-prime-minister-boris-johnson-hails-drug-dexamethasone-as-the-biggest-breakthrough-yet/
COVID-19: Boris Johnson Calls Dexamethasone “Biggest Breakthrough Yet”
Speaking at his daily Downing Street briefing, Prime Minister Boris Johnson said there was a genuine case to celebrate “a remarkable British scientific achievement,” adding: “We have taken steps to ensure we have enough supplies, even in the event of a second peak.”

Johnson also called dexamethasone the “biggest breakthrough yet” in the hunt to find a long-term solution for COVID-19. In April, the prime minister spent a week in London’s St. Thomas hospital being treated for the respiratory illness, receiving oxygen while in intensive care for three days of his stay./i]

Offline Prepper456

  • Survivor
  • ***
  • Posts: 168
  • Karma: 7
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1325 on: July 30, 2020, 06:40:14 PM »
More to the point, since hydroxychloroquine is safe, why not let doctors prescribe it just like they are doing in several other countries? 

France, Italy, Germany, and Belgium announced they would ban the use of hydroxychloroquine to treat coronavirus patients after recent studies revealed serious safety issues with the anti-malaria drug.



Offline iam4liberty

  • Survival Veteran
  • ********
  • Posts: 5063
  • Karma: 358
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1326 on: July 30, 2020, 07:50:47 PM »
France, Italy, Germany, and Belgium announced they would ban the use of hydroxychloroquine to treat coronavirus patients after recent studies revealed serious safety issues with the anti-malaria drug.

No.  The Lancet was forced to retract the fake study on which that decision was based..  In fact, Dr. Didier Raoult Is now suing Martin Hirsch, the director of the Public Hospitals of Paris, after her used the fake data to defame him in the hearings.  The trials are back on.

In fact, three randomized, double-blind, placebo-controlled trials show that the prescribed hydroxychloroquine treatment is safe.

https://www.politico.eu/article/france-clamps-down-on-hydroxychloroquine-use-for-covid-19/
France clamps down on hydroxychloroquine use for COVID-19
Move follows publication of a study casting doubt on the drug’s benefit for COVID-19 patients.


Update: The Lancet hydroxychloroquine study was on June 4 retracted by the authors, who said they cannot “vouch for the veracity of the primary data.”


https://www.rfi.fr/en/france/20200730-didier-raoult-files-false-testimony-complaint-against-paris-hospital-director-hirsch-coronavirus-deaths
French medical doctor Didier Raoult is suing the director of Paris' public hospitals body for defamation following accusations that Raoult lied under oath during a parliamentary hearing on the coronavirus crisis.


https://www.news-medical.net/news/20200727/Clinical-Trials-of-Hydroxychloroquine-in-COVID-19-Outpatients-Are-Safe.aspx
Clinical trials of hydroxychloroquine in COVID-19 outpatients reported as safe

According to new research published in the preprint server medRxiv* in July 2020, the use of hydroxychloroquine (HCQ) among outpatients in clinical trials, without high-risk factors for cardiac arrhythmia, is safe, with gastrointestinal side-effects being the most common side effects and no fatal adverse outcomes.

Offline FreeLancer

  • Global Moderator
  • Survival Veteran
  • ******
  • Posts: 6696
  • Karma: 819
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1327 on: July 30, 2020, 10:24:10 PM »
Cumulative Cases/Deaths per Million Population

Nation/State         Cases/mil Deaths/mil
Peru 12,345576
Chile 18,481490
US13,996 469
Brazil12,290430
Mexico3,225356
Panama 14,859 323
Canada  3,066236
--- --- ---
New Jersey 21,0511,789
New York22,7721,684
Massachusetts ^x116,9891,247
Connecticut 13,9321,243
Rhode Island  17,888951
Louisiana ^x124,626845
Washington, DC17,084827
Michigan8,990645
Illinois 14,058 605
Delaware ^x215,085597
Maryland 14,420577
Pennsylvania 9,050568
Mississippi 19,347541
Arizona ^x123,465498
Indiana 9,693438
Georgia 17,169346
South Carolina ^x717,009324
Alabama ^x217,491319
Colorado 8,023316
Florida ^x521,482307
New Hampshire 4,813305
New Mexico ^x19,723303
Ohio ^x17,669295
Minnesota 9,520290
Iowa 13,960272
Nevada ^x115,202260
Virginia 10,416251
Texas ^x414,943231
California 12,503228
Missouri 8,043210
Washington7,547206
North Carolina 11,499184
Nebraska 13,320170
Kentucky 6,577164
Wisconsin 8,950158
Tennessee ^x115,063151
Arkansas ^x113,838146
South Dakota 9,817146
Oklahoma ^x19,032135
North Dakota 8,268135
Kansas 9,331122
Idaho ^x311,32999
Utah ^x212,38294
Maine ^x12,89291
Vermont 2,25591
Oregon 4,29975
West Virginia 3,58364
Montana ^x13,569 51
Wyoming 4,64145
Alaska 3,93431
Hawaii 1,40518


South Carolina, Texas, and Florida all moved many rungs up the death ladder in the last week.

The 7-day moving average daily deaths has been above 1,000 the last two days, which is double the rate the US had dipped to at the beginning of July.

Offline iam4liberty

  • Survival Veteran
  • ********
  • Posts: 5063
  • Karma: 358
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1328 on: July 31, 2020, 07:16:25 AM »
There’s no shortage of docs willing to prescribe hydroxychloroquine, if you want it.

Indeed, many doctors see the benefit of prescribing it, both for patients and their staffs . That is why the medical authoritarians have been targetting pharmacists around the country, threatening to revoke their licenses if they don't get on board with their politically driven demands.

https://amp.usatoday.com/amp/5547751002
Ohio pharmacy board reverses ban on hydroxychloroquine

The State of Ohio Board of Pharmacy has changed course on its ban of hydroxychloroquine and chloroquine as coronavirus treatments
...
Beginning Thursday, pharmacies, clinics and other medical institutions were to be prohibited from dispensing or selling the drugs to treat COVID-19, according to regulations issued by the State of Ohio Board of Pharmacy.
...

DeWine said the decision of how to treat COVID-19 should instead be between patients and their doctors.

“The Board of Pharmacy and the State Medical Board of Ohio should revisit the issue, listen to the best medical science, and open the process up for comment and testimony from experts,”
...
Under the regulation, pharmacists in Ohio found to be selling or dispensing the drug to treat COVID-19 could have faced disciplinary action ranging anywhere from a warning or fine to a temporary suspension of their license.
...
the Ohio Board of Pharmcy cracked down on doctors who were hoarding hydroxychloroquine for themselves, family and friends
...
On April 20, Capital Wholesale Drug in Columbus donated 2 million hydroxychloroquine pills — worth about $680,000 — from drug maker Prasco, which is based in Mason, Ohio.
 .
“The company that donated the 2 million pills is taking them back,” Amato said via email Wednesday.

Offline iam4liberty

  • Survival Veteran
  • ********
  • Posts: 5063
  • Karma: 358
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1329 on: July 31, 2020, 08:54:13 PM »
Jack's open challenge.  Definitely worth the read and listen.

http://www.thesurvivalpodcast.com/an-open-challenge-to-debate-any-scientist-or-doctor-on-the-merits-of-hcq-for-the-treatment-and-prevention-of-covid
An Open Challenge to Debate Any Scientist or Doctor on the Merits of HCQ for the Treatment and Prevention of CoVid

The Open Challenge

I have been trying to do this since March and have ramped it up hard in the last week, I have had no takers on this issue.  I am open to other points of debate but specifically here are 9 points of debate I want to have with any professional about hydroxychloroquine, (hereafter referred to as HCQ in this article) as it relates to CoVid and the prevention and treatment of it.

1. HCQ is safe and the claim it should only be used in a hospital is a blatant lie
2. HCQ is a zinc ionophore which means it gets zinc inside of human cells and this is known science
3. Zinc in the human cell disrupts viral replication of mRNA replicating viruses and this is known science
4. No RCT has included zinc as of 7-31-20
5. All negative RCTs overdosed patients and did not include zinc, most were in late stages of the illness when the lungs were already severely damaged
6. There are multiple positive studies that counter the negative studies
7. The existing studies are so flawed that it at least appears intentional (over dosing, late stage use and the omission of a critical component of care)
8. There is ample evidence to support the use of HCQ for covid treatment and prevention
9. Doctors should not be banned from prescribing HCQ for any use they feel would be of benefit to a patient

Offline iam4liberty

  • Survival Veteran
  • ********
  • Posts: 5063
  • Karma: 358
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1330 on: August 01, 2020, 06:56:03 AM »
The bias against hydroxychlorquine is literally now a subject in the medical ethics journals.  Dr. Harvey A. Risch, MD, PhD and professor of epidemiology at Yale School of Public Health, made a prognostication in his courageous open letter:  "In the future, I believe this misbegotten episode regarding hydroxychloroquine will be studied by sociologists of medicine as a classic example of how extra-scientific factors overrode clear-cut medical evidence."  It has already come true.

https://theprint.in/health/researchers-smell-a-rat-say-expensive-remdesivir-getting-subtle-push-over-hcq-in-studies/471983/?amp
Researchers smell a rat, say expensive remdesivir getting ‘subtle push’ over HCQ in studies

A “subtle push” is being given to remdesivir (RDV) as a treatment for Covid-19 while hydroxychloroquine (HCQ) is being “snubbed” despite the two drugs showing similar results with respect to coronavirus, a group of researchers has said.
...
The IJME is India’s only journal on bioethics and medical ethics, and is published by the Forum for Medical Ethics Society (FMES)
...
According to the researchers, HCQ appears to be courting greater scrutiny with respect to safety and efficacy, and risks associated with the much more expensive remdesivir seem to be getting played down.

The fact that this may be driven by “political affiliation, profiteering, and other conflicts of interest cannot be ruled out at this stage”, they say in an article titled “Hydroxychloroquine and Remdesivir (RDV) in COVID-19: A critical analysis of recent events” and published in the July-September print issue of the quarterly journal.   

“Criticism of HCQ has been focused on safety (increased risk of adverse events and arrhythmias), followed by efficacy (lack of clinical or mortality benefit). However, there has been no acknowledgement of the high dose of HCQ given [during trials] when compared to the lower dose recommended by the Indian Council of Medical Research (ICMR),” they write.

“On the other hand, the lack of mortality benefit with RDV is being downplayed, and attempts to highlight a lack of new safety risks, despite observations to the contrary, are repeatedly made. It appears as if HCQ is being more closely scrutinised when compared to the lighter treatment given to RDV,” they add.
...
“confounders such as political affiliation, profiteering, and other conflicts of interest cannot be ruled out at this stage, with the available evidence and information”.
...
“The safety profile of HCQ is well-known since it has been in use for various other conditions as well. On the other hand, RDV has not been in long-term use for any other condition, and lacks a clear safety profile,” the researchers note.
...
“It appears that a subtle push is being given to RDV, the safety of which is not adequately established; while HCQ is being subtly snubbed, despite both drugs having similar efficacy patterns.”

This, the researchers say, appears to be in “contravention of the basic ethical principles of beneficence, non-maleficence, autonomy, and justice”.

Offline Mr. Bill

  • Like a hot cocoa mojito
  • Administrator
  • Ultimate Survival Veteran
  • *******
  • Posts: 15270
  • Karma: 1875
  • Trained Attack Sheepdog/Troll hunter
    • Website Maintenance and Online Presence Management by Mr. Bill
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1331 on: August 02, 2020, 01:53:45 PM »
Reuters, 8/2/20: U.S. coronavirus 'extraordinarily widespread', say White House experts

Quote
...“We are in a new phase,” said Dr. Deborah Birx. “What we are seeing today is different from March and April. It is extraordinarily widespread” in rural as well as urban areas.

“To everybody who lives in a rural area: You are not immune or protected from this virus,” Birx said on CNN’s “State of the Union.”

Birx, the White House task force coordinator, said people living in multigenerational households in an area that is experiencing an outbreak should wear masks inside the home to protect the elderly or those with underlying conditions.

Admiral Brett Giroir, an assistant Health and Human Services secretary, continued to stress the importance of wearing masks.

“If we don’t do that, and if we don’t limit the indoor crowded spaces, the virus will continue to run,” he said on NBC’s “Meet the Press.”  ...

Offline surfivor

  • Survival Veteran
  • ********
  • Posts: 7495
  • Karma: 115
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1332 on: August 02, 2020, 02:08:23 PM »
How do they know, is predicting future disease outcome a proven and known field of science or is it just theory or anyone's guess ?

Offline Mr. Bill

  • Like a hot cocoa mojito
  • Administrator
  • Ultimate Survival Veteran
  • *******
  • Posts: 15270
  • Karma: 1875
  • Trained Attack Sheepdog/Troll hunter
    • Website Maintenance and Online Presence Management by Mr. Bill
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1333 on: August 02, 2020, 02:59:00 PM »
How do they know, is predicting future disease outcome a proven and known field of science or is it just theory or anyone's guess ?

Epidemiology for the uninitiated, from the BMJ.

Offline surfivor

  • Survival Veteran
  • ********
  • Posts: 7495
  • Karma: 115
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1334 on: August 02, 2020, 03:43:00 PM »
I googled epidemiology got it wrong and got quite a lot of results

https://www.google.com/amp/s/reason.com/2016/12/23/an-epidemic-of-bad-epidemiology/%3famp

Offline Mr. Bill

  • Like a hot cocoa mojito
  • Administrator
  • Ultimate Survival Veteran
  • *******
  • Posts: 15270
  • Karma: 1875
  • Trained Attack Sheepdog/Troll hunter
    • Website Maintenance and Online Presence Management by Mr. Bill
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1335 on: August 02, 2020, 06:52:33 PM »
I googled epidemiology got it wrong and got quite a lot of results

You Googled what you wanted to find, and you found lots of results, so let's throw out the whole science of epidemiology.

Come on, this news is straight from Deborah Birx, the Trump administration's hand-picked COVID-19 coordinator for the past 6 months.  If you can't trust the Trump administration's warnings about the virus, who can you trust?

Maybe everything will turn out way better than Birx and the epidemiologists predict.  Or maybe it won't.  That's the whole point of prepping, isn't it?

Offline Greekman

  • Survival Demonstrator
  • *******
  • Posts: 4018
  • Karma: 206
  • New TSP Forum member
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1336 on: August 02, 2020, 09:46:03 PM »
Reuters, 8/2/20: U.S. coronavirus 'extraordinarily widespread', say White House experts

for the first part, it is what we are seeing in Greece ATM.

For the rural part, it is an expected phenomenon...Such a case that "the virus recedes in the populated areas adn make short spreads in the rural, to recede again" was presented to us in the Epidimiology Coursera webinar I took.

Offline Mr. Bill

  • Like a hot cocoa mojito
  • Administrator
  • Ultimate Survival Veteran
  • *******
  • Posts: 15270
  • Karma: 1875
  • Trained Attack Sheepdog/Troll hunter
    • Website Maintenance and Online Presence Management by Mr. Bill
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1337 on: Yesterday at 03:37:16 PM »
Another low sample size, somewhat limited representative study. (sigh)  But at least this one included zinc in early treatment and confirmed positive COVID patients .  The results are in line with earlier ones demonstrating dramatic efficacy of the combination. A strong meta-analysis case is forming.

https://www.prnewswire.com/news-releases/newly-published-outpatient-study-finds-that-early-use-of-zinc-hydroxychloroquine-and-azithromycin-is-associated-with-less-hospitalizations-and-death-301094237.html
Newly Published Outpatient Study Finds that Early Use of Zinc, Hydroxychloroquine and Azithromycin Is Associated with Less Hospitalizations and Death

Here's a preprint of the study (version 1, which the authors acknowledge has at least one important misprint):
COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study

The major flaw in this study (besides the small sample size) is that there is no control group.  Comment #23 discusses this in detail:

Quote
The treatment population are patients who presented to their family doctor with mild symptoms. The paper presents this as a strength, as the 'first outpatient study,' which fair enough. It also means that these were almost certainly patients who were less sick than average at presentation. This needs to be clearly reflected in the control group.

There is no control group. There is a comparison group, selected ad hoc after the fact, from some source of data for patients in the same community. We don't know the severity at presentation, or the treatment history, of that comparison group. The paper seems to indicate that neither do the authors. That isn't a controlled study, it's a case series with a seemingly random comparison grafted on after the fact.

We have no idea what the data source for the comparison group is. Literally, none. The authors say it's publicly available community data, but they refuse to name the data source. We have no idea of the characteristics of patients in the control group. None, nada, zilch. All we know is how many there were, how many were hospitalised, and how many died. As one of the comments already points out, we don't even know whether some of the 'controls' might have also gotten the triple therapy.

The authors cite HIPAA to say they can't disclose the data source for the control group. This is confusing. If it's public data, it's public data. Cite the public data source. If it's not public data, that statement is at best misleading. One cannot simply say 'this data came from somewhere, but I can't tell you where,' and expect it to be taken as science.

In the comments, authors respond to this criticism by saying they selected the controls very conservatively. Which means they selected control patients from that undisclosed data source. They don't disclose the selection criteria. We have no idea how they selected the controls from the data source that they also won't disclose. They won't tell us. That's not science.

Given all this, it's entirely possible the 'control group' were patients presenting at the OR with severe disease, who received triple therapy and were hospitalized and died. A reader evaluating your data simply has no way to know.

They make a great deal throughout the paper that treated patients have a much lower death rate than controls. It's one of the major claims of the paper. We have no idea what the control group is, so we don't know if the difference is relevant. But more, that difference is not even statistically significant. The stats show that there is no significant difference in death rates.

Unless I missed something, the authors disclose this in only one sentence, and in one data table, where they show that for mortality, p=0.16, without flagging it as not significant. In fact, they attempt to excuse it, by saying in effect that the lack of significance is caused because they don't know enough about patients in the comparison group. That doesn't save the claim. Rather the opposite, in fact.

It's a case series, not a "case series study." The inclusion of the comparison group in this form is worse than useless, it's actively misleading. If HCQ in any treatment regime actually works, which seems increasingly unlikely based on randomized trials, this paper does a disservice to advancing our knowledge of that fact.

Y'know, I'm trying to give this Zelenko Protocol thing a fair chance.  But all he's got is a hypothesis, and a collection of case results that seem to make a pattern if you blur the background and squint at a 37-degree angle.  I'm just not seeing the overwhelming evidence of success that ought to be obvious after all these months.

I also don't understand why some folks are all excited about one famous epidemiologist who likes HCQ, but ignore all the other famous epidemiologists who say just the opposite.

There's a whole lot of not-really-science going on here, and too much willingness to believe that the fifty zillion anti-HCQ doctors and researchers have all been corrupted or misled by the Big Pharma/Democrat conspiracy.  Maybe they do really know what they're talking about.

Offline FreeLancer

  • Global Moderator
  • Survival Veteran
  • ******
  • Posts: 6696
  • Karma: 819
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1338 on: Yesterday at 09:16:11 PM »
I also don't understand why some folks are all excited about one famous epidemiologist who likes HCQ, but ignore all the other famous epidemiologists who say just the opposite.

There's a whole lot of not-really-science going on here, and too much willingness to believe that the fifty zillion anti-HCQ doctors and researchers have all been corrupted or misled by the Big Pharma/Democrat conspiracy.  Maybe they do really know what they're talking about.

"A man hears what he wants to hear and disregards the rest......."

Offline Mr. Bill

  • Like a hot cocoa mojito
  • Administrator
  • Ultimate Survival Veteran
  • *******
  • Posts: 15270
  • Karma: 1875
  • Trained Attack Sheepdog/Troll hunter
    • Website Maintenance and Online Presence Management by Mr. Bill
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1339 on: Yesterday at 09:32:56 PM »

Online Morning Sunshine

  • Geese Smuggling Moonbat
  • Survival Veteran
  • ********
  • Posts: 6527
  • Karma: 310
  • There are no mistakes, just Learning Experiences
Re: Coronavirus COVID-19 (a.k.a. 2019-nCoV) outbreak in China
« Reply #1340 on: Today at 06:45:55 AM »
What did you say?

"hmmm, hm hm, hmmmmm"